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complete dominance

BiologyGeneticsMendelian inheritance

Summary

Complete dominance means one allele fully masks the other in a heterozygote, so Aa looks the same as AA. The most testable point: an Aa × Aa cross typically gives a 3:1 dominant to recessive phenotype ratio and a 1:2:1 genotype ratio.

Detail

Meaning: In complete dominance, the dominant allele produces a phenotype that fully masks the recessive allele when both are present, so the heterozygote (Aa) looks like the homozygous dominant (AA). Typically the dominant allele encodes a functional product, so one working copy is enough, while the recessive allele often encodes a nonfunctional product. Only the homozygous recessive (aa) shows the recessive phenotype.

On the MCAT: Expect Punnett squares and pedigrees. Aa × Aa typically gives 3:1 phenotypes and 1:2:1 genotypes. A test cross (unknown × aa) shows the genotype: any recessive offspring means the dominant-phenotype parent is Aa. In pedigrees, two unaffected parents with an affected child suggest a recessive trait; two affected parents with an unaffected child suggest a dominant trait. Contrast it with incomplete dominance (intermediate phenotype) and codominance (both alleles expressed, as in AB blood type).

Common confusion: Students treat dominant as stronger, better or more common. Dominance describes the heterozygote's phenotype, not how common an allele is. A dominant allele can be rare and a recessive allele common. Allele frequency depends on forces such as selection, drift, mutation and gene flow (departures from Hardy-Weinberg equilibrium), not on dominance.

Sources

  • Campbell Biology
  • Genetics: A Conceptual Approach
  • Principles of Genetics

Written for the MCAT and checked before it was published. For study reference only. Spotted an error? Let us know.

complete dominance: MCAT Glossary